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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

“That’s the first time we’ve seen that,” said Thomas Karl, director of the US National Oceanic and Atmospheric Administration’s national centres for environmental information.
玛多问道:"特鲁多承诺在上任之后,内阁中将有50%是女性。如今他兑现了承诺。那么你也会做出类似承诺吗?"

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
From the themed collection: 大爆发,石英石产业发展新局面
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

About 60 per cent have not yet worked and a further 30 per cent have less than two years’ experience.
他还贴出了一张自己看着一群种族多元化儿童的图片。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

A tender love story between a teenager and an academic, set in Italy.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Just 21 millimeters long, 16 millimeters high, and 4 millimeters thick, the amulet, of which part is missing, has a “raised decoration” on it with a loop at one end that allowed it to be worn on a cord around the neck.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

2013年排名:1
A record 27,817 civil service jobs are being offered this year by central government departments and subsidiaries.
n. 检查,支票,账单,制止,阻止物,检验标准,方格图案
10. 《结果》(Results),导演:安德鲁·布西内斯克(Andrew Bujalski)。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

但对于北京来说,若能在特朗普让美国退出TPP后不到一年的时间里达成RCEP协议,将是一场巨大的胜利。
谨祝新年快乐幸福,大吉大利。
其实,它体现在所有品牌上,它们把六七十年代的服装搬到当季店铺里,包括阿尔伯特·菲尔蒂(Alberta Ferretti)、璞琪(Pucci)和艾绰(Etro)。
韩国最大的整形医院之一,由权株创立的JK整形手术中心,近期开了一家旅馆来更好地服务顾客。这些顾客每次看病人均花费17675美元。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Before long, Russell fell in love with inmate named Phillip Morris. After Morris was released, Russell again escaped prison by calling the clerk's office, impersonating a judge and drastically reducing his own bail. He was caught and escaped two more times to be with Morris, at one point faking his own death. He is now serving a life sentence but admits to finding his film portrayal pretty exciting.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

syndrome

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
From the themed collection: 2017家居圈大变革 你准备好了吗?
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Further, 32 out of the 50 new selected female billionaires started their businesses from scratch.
10. “移动珠宝”(Run the Jewels),《移动珠宝2》,Mass Appeal。说到迫切和讥讽,杀手麦克(Killer Mike)和EL-P都是地下说唱界不同圈子里的资深人士了,他们组成的“移动珠宝”在第二张专辑里找到了坚实的互相吸引。他们的说唱强大有力,关注点狂热喧闹,专辑抨击没有让任何人摆脱困境的权力结构。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

With a bit of help from Charles Dickens, let’s take a look back at the year in which almost nothing worked:
For: A huge box office hit that could benefit from a slowly-changing Oscar voting demographic.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

4. Manufacturing won't save the economy.
['p?li?]

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

除了作品被展示在谷歌主页,张天羽还获得了3万美元的大学奖学金。她所在的学校也将获得5万美元的谷歌教育科技拨款。谷歌还以她的名义向慈善机构捐赠了2万美元,用于给孟加拉的学校提供净水。
8. Get Inspired
先锋(Vanguard)的亚洲投资组合审查主管Yan Pu怀疑,亚洲的产品结构可能阻碍了ETF的发展。例如,亚洲ETF公司提供大量的股票ETF产品,但很少有固定收益产品。她指出,在美国,固定收益ETF增长迅速。
badminton;basketball;fencing;Judo;Ping Pang;taekwondo;Tennis;weightlifting;Wrestling;Volleyball;Boxing;Hocky.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

紧缩政策促使一些企业寻求其他融资方案,比如债券或在全国中小企业股份转让系统上市。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

中国的股市能否重回6000点?
两名美国人因研究医生与医院、学生与学校和人体器官与被移植者之间的有效匹配,昨天被授予诺贝尔经济学奖。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

在这份榜单的前二十人中,C罗和梅西是仅有的两名足球运动员,此外,这份榜单上也没有任何女性运动员入围。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 智能家居变革“从手控到声控”
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

美国经济将会表现得更好就算世界上其他地区没能做到

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

Interestingly, BRICS bloc has reduced their exposure to these securities at a time when America's economic activity is expanding at a moderate rate.
If successful, Hurun estimates that Mr Wang’s net worth could soar past $50bn, making him one of the world’s 10 richest men.
每次我跟人说起“未来”,我都被他们对“未来是可知”的这一想法吓到。我的印象就是,大部分人都想象未来像书本一样,有一个结局:已经写好了、也可以读取。你只要快速地窥一眼这本书的最后几页就能知道。他们很难接受这最后几页根本没有写完。未来还没有发生、也没有计划好——也无法预知,因为它们还根本不存在。
改革就是要解放和发展生产力,调动广大人民的积极性,让群众得到实惠,为政之要就是要舍小利、顾大义、顺民心。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

单词complex 联想记忆:
“十二五”期间,中国累计实际使用外资预计达到6200亿美元,第三产业实际利用外资占比提高到60%以上。同期中国对外直接投资年均增长14.2%。
3. Tablets meet viruses.
Hope you enjoy the happiness of New Year and all the trimmings.
如果你是一名创业家,那么未来永远是光明的,基于传统服务的数字化来创立新企业的机会简直取之不尽。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

Judge for yourself.
3) I am often irritated 0 1 2 3 4

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

而是穆斯克在会上表示,预计特斯拉到2015年底将实现10万台的年产量。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

23岁的古纳尔?优素福(Gunal Youssouf)是Teach First人,她加入了普华永道(PwC)英国分公司的管理咨询毕业生项目。优素福表示,在Teach First的两年让她有机会在不用花钱攻读传统资格证书的情况下尝试教学工作。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

Alice Schwarzer
QuikTrip
不包括阿拉斯加和夏威夷在内的美国本土曾在2012年创下温度记录,那年发生过灼人的热浪和干旱。主要是由于东部地区不同寻常地寒冷,才使得2014年的温度对这48个州来说,仅在有记录以来的最暖年度中排名第34。
Lady Gaga以5.9千万位列第四,其后是5.45千万的碧昂斯。前者在统计期间演出了66场,也靠与范思哲和MAC的合约获得收入,同时还有她自己的黑色香水。后者与其老公Jay Z的On The Run巡回演唱会通过19天(北美日期),赚得了超过10千万,创造了能与滚石相比较的第一对音乐界夫妻档夜平均的神话。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
From the themed collection: 定制家具有望保持18%增速
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

她说道:“我认为,由于这家公司没有打击盗版或其他恶意修改游戏行为的能力,所以他们把一个14岁的孩子当替罪羊来以儆效尤。”
Roth, 60, is a professor at Harvard University in Boston. Shapley, 89, is a professor emeritus at University of California Los Angeles.
However, you know when your cycles are over when the washer and dryer stop making noise. And you know when the weather is ugly by simply looking outside, or checking your weather app. Therefore, the product is basically just another way hackers can get into your home.
"A total of 297 projects will be carried out in Tongzhou, such as building new subway lines and expressways, and improving ecologies," Lu Yan, director of the Beijing Municipal Commission of Development and Reform, said at a news conference on Wednesday.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

4=是
optimistic

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: 发改委酝酿光伏电价系列新政
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Master of None
Wishing you peace, joy and happiness through the coming year.在新年来临之际,祝福你平安、快乐、幸福!
会计和咨询机构德勤(Deloitte)英国分公司的企业责任主管克莱尔?伯顿(Claire Burton)表示,Teach First出来的人很受招聘人员的欢迎,因为他们擅长团队合作,有很强的领导能力。
Lawyers are inherently cautious but most have realised that technology is crucial to crunching through the vast amount of information they handle. Without it, certain document heavy processes, such as disclosure and compliance, would be nearly impossible.
Meanwhile, in recent months mainland investors have been rapidly owning equity trading accounts and putting money into the stock market. The Shanghai Composite has become the region's best performing index, rising nearly 45 per cent year to date.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

FKA twigs “Two Weeks” (Young Turks)
9. Occupational therapist
报告显示,与2015年相比,2016年选择创业的应届毕业生比例明显下降,由6.3%降至3.1%。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

[ri'dikjul?s]
enterprise

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

n. 支柱,
But we at The BostonConsulting Group believe that the current dip in China’s growth will not endureand that, under Xi’s leadership, China’s economy is destined to continuegrowing at a rapid clip. In fact, we are confident last week’s reforms willcontribute mightily to China’s growth between now and 2020. We stand by our base case forecast that China will deliver$4 trillion in growth over the next decade and combine with India to deliver a$10 trillion prize — an economic powerhouse driven by booming middle classconsumption and growing overall optimism. No one can perfectly forecastthe future … and in our book we describe scenarios where growthslows. But we remain optimistic and positive about China’s future.
此次涵盖95个项目(去年为90个)的排行榜中,来自7个国家的9所院校为首次进入榜单。排名第41位的法兰克福金融管理学院(Frankfurt School of Finance & Management)是今年排名最高的新入榜者。这家德国学院拥有性别比例最平衡的项目之一,女性占学员总数的49%。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

当你听说今年3月份,一个17岁的学生把自己设计的一款软件以3,000万美元卖给雅虎公司(Yahoo! Inc., YHOO)的时候。对于这孩子的形貌,你脑海里或许已勾画出一个搞笑的形象了吧:不用说,肯定是个极客。一个除了一行一行写代码之外对什么也不感兴趣的学霸。一个不敢正眼瞧人还老小声儿嘀咕着什么的神经质。
答:这是我第一次去旧金山。非常美丽的城市。到那儿的第一天我们就去看了金门大桥。海湾的景色真是让人愉悦啊。我在日本每次看电影,这个城市和这个桥都要被毁一次。但我从不知道这个城市亲眼看的话居然有这么美。下次再来可能就没机会看这座桥了,所以我很高兴这次能看到。
这两部纪录片都使用标准工具——资料影像、人物采访,悉心选择的音乐资料——在目前的紧张局势中书写历史。在“黑人的命也是命”(Black Lives Matter)的时代,关于黑豹党和爵士歌手兼行动分子妮娜·西蒙妮的影片确实意义重大。尼尔逊和贾巴斯精彩地讲述了他们的故事。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 我国城乡低保标准再提高
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

This is the sixth edition of the QS World University Rankings by Subject, featuring a record-breaking 42 disciplines, making it the largest-ever ranking of the kind. The expert opinion of the world's top 76,798 academics and 44,426 employers informed the results, alongside the analysis of 28.5 million research papers and over 113 million citations sourced from the Scopus/Elsevier bibliometric database, said QS.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

卓越雇主排名:25

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Company: Binary Group
例如比利时,它的人口不到小组赛对手俄罗斯的1/10,但被认为是一个巨大的威胁。而乌拉圭尽管人口还不到400万——仅仅是大圣保罗人口的1/6——却是巴西在通往决赛之路上最不想碰到的球队之一。为何如此呢?

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

发脾气大奖
“One employee’s parents contacted the company to let us know their son was resigning.
For example, taxi drivers who take a detour or refuse passengers can also be fined a maximum of 2,000 yuan.
You`d love to know the balance of forces that shape and move your ponytail, right? That`s why Joseph Keller, Raymond Goldstein, Patrick Warren and Robin Ball received this igNOMINIOUS prize!

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 大连香格里拉大酒店项目材秀
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

The report shows that compared with that in 2015, the percentage of graduates to start up business are significantly decreased from 6.3% to 3.1% in 2016.
Lady Bird

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

“一般人很难发现你们在做什么,但是你的异常却很容易被经理们捕捉到。”凯说。许多情况下,你漫不经心,或者如凯描述得那样:“精神完全不在状态。”或许你过去常常积极参与会议,但是你现在沉默了。或许你没有过去做得多了。或许你不再对你要做的案子感兴趣了。
凯莎《彩虹》

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

These artificial ears will be a huge benefit to those who suffer injuries or who have microtia, a condition that keeps the ears from ever developing.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

STEP 1: GET THE LOOK
Yet for all Russia's pretence about a rebalancing of priorities towards Asia, since the fallout over Ukraine, it still measures itself against the West, and America in particular.
In fact, one ancient saying was, "ifyou have Kucha, only one percent of the states in the Western Frontiers remain unsubmissive."
n. 锦标赛,冠军,拥护

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
From the themed collection: 2014年青海32.5复合水泥产量将减半
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

[p?'spektiv]
n. 城堡

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

这支在11月有着过半胜率的不断进步的球队完全不是垫底球队,这是一支严格意义上的可能的季后赛球队,但是就像所有重建中的球队都会讨论的那样,是靠现有球员和上场时间来换取当下的胜利呢,还是更关注于可持续性的发展呢?
Five development concept of innovation, harmonization, green, openness and sharing
小说作者安东尼·赫洛维兹(Anthony Horowitz)透露,新书《Trigger Mortis》为现代读者作了改动,包含反对吸烟的信息,而且首次有一位“直言不讳”的同性恋朋友出场。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

We think of the passage of NBA time in seasons, for obvious reasons. There's connection, a continuum. It's how we remember things that happen, in the course of a season of play. But there's some benefit to looking back at a calendar year, January 1 to December 31, and what we've learned in that process. After all, many say the "unofficial start" to the NBA season is Christmas, with the new year starting soon after. So here are the lessons we learned about the NBA in the year 2017.
10.Be Dedicated and balanced
9、另一地球

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

3. 向他人学习。
If you are spending time looking for other jobs while you are on the clock, it's obvious you want to leave your job. So keep looking for new jobs and as soon as you find a good one, take it and run.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

allure
Venice has long been hailed as one of the most romantic cities in the world, a must-visit lagoon city on many people's travel lists.
1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4:狂暴之路》(Mad Max: Fury Road),并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片,二者都应该到你能找到的最大的屏幕上去看。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Game of Thrones
"The Constitution really doesn't apply here. The Constitution limits how much government can suppress speech, not a private university," she said.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

5Japan
中国几乎所有的黄金都用于满足国内需求,因为中国不允许企业出口黄金。
煽动家的运动自然导致了专制统治——多数人的暴政掩盖了一个人的暴政。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Anxiety about addiction to screen time gave rise to a dubious new line of businesses: boot camps, often run by ex-military personnel, promising to help wayward youth kick the habit. But investigative reports p ublished in recent days by Beijing News and the Mirror reveal abusive conditions, leading to the death of at least one student, at the Zhengzhou Boqiang New Idea Life Training School, which billed itself a s an Internet-addiction recovery camp in eastern Henan province.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 北京地下室住户两天搬进新家
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

位于华盛顿特区的乔治敦大学(Georgetown University)麦克多诺商学院(McDonough business school)重新回到了定制课程排行榜的第15位,去年,该校因客户调查反馈率低而未上榜。只有3所学校是首次登上定制课程排行榜,包括排名第60位的伦敦卡斯商学院(Cass Business School)。
就业增长超出预期;

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Jackdaw Research的简?道森(Jan Dawson)表示,最近几个月“他表现得更加意气风发和充满自信”。
周二在西弗吉尼亚州的贝灵顿一个人在雪地里行走。星期二飓风桑迪使得西弗吉尼亚州的部分地区被超过一英尺的雪所覆盖。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

这份报告还指出,中国现在共有594名以美元计的亿万富翁,这一数字超越了美国的535名,但是并没有一名中国富翁进入全球首富前20名。
Both the film and the television series are adapted from the Taiwan action role-playing game of the same name which was developed by Softstar Entertainment. The game is considered by many as simply one of the best Chinese RPG's ever created.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

8、苹果发布会
Included will be messages about smoking causing cancer and women who give the charmer a run for his money as 'little twists' have been added to make the story suitable for the modern reader.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

当然,这得取决于苹果是否能设法用更便宜的零部件、更慢的处理器、分辨率更低的屏幕、以及也许是塑料机身来造出一部330美元的iPhone。而用蒂姆?库克上周在高盛公司(Goldman Sachs)一次会议上的话说,它决不能是个“低劣产品”。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Many investors, it turns out, are siding with Mr Cook. After a tumultuous 2013, the share price has increased by around 50 per cent since that shareholder meeting, at one point taking its market capitalisation above $700bn.
adj. 暴露的,无掩蔽的,暴露于风雨中的 v. 暴露,
圣加伦大学校友在毕业3年后的平均年薪增至10.2万美元,去年这个数字为9万美元。
GAINS AND LOSSES IN A CHANGING WORLD

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

The GM turnaround will drag on. Forget a 2010 IPO.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

中国国家统计局数据显示,10月份,食品价格的再次放缓拉低了中国的通胀率。
Institutions may also fail.
苹果越来越需要有人去抵挡和应对攻击者以及监管者(苹果在欧洲遭到税务调查),而库克对人、策略和执行——而不是产品——的重视终于开始看起来像个优势。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

各大资产管理公司的专家们表示,评估亚洲ETF潜力的难题在于日本市场在地区所占比重过大,以及日本央行(Bank of Japan)扮演的角色过大。日本央行每年购买6万亿日元(合540亿美元)的ETF,这扭曲了市场。
Qualcomm

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

007系列电影主题曲第九名:露露--《金枪人》
Forever pop's Number One rebel, Charli XCX returned with an excellent surprise mixtape.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

达洛伊西奥常喜欢说“时间是新的货币”。这是一个17岁男孩对人生的睿智洞察,也是Summly软件背后的发展理念。而我们多数人在他那个年龄,时间多得都不知道该怎么做才不会荒废。我很容易就忘了这样一个事实:达洛伊西奥在1995年出生于一个中上层阶级家庭,连高中都还没毕业,还住在小时候住的那个舒服卧室里。在我和他父母聊天的时候,他离开房间去在电脑上干活。只见他穿着袜子下楼,牛仔裤腿扫过大厅的地毯──此时此刻是他最像个孩子的时候。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Mrs. May’s government proposed a rule that would publicly shame employers who hired foreign workers. And her first major speech was full of barbs directed against multiculturalism, including a jab against people who claimed to be “citizens of the world,” whom she called “citizens of nowhere.”
When you post your résumé to a job board, such as Monster or Indeed, there's a chance your current employer could see it. In fact, Foss says many HR staffers and managers regularly search for their company names within job board submissions specifically to see if their employees are looking for jobs。
“学会让经济指标和人民主观的幸福感同步发展是很重要的,因为我们应该不仅仅是追求更强的经济能力,而应追求提高各个领域生活质量。”报告总结道。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

“纽约人正逐渐意识到,这一漫长的繁荣期已对我们眼中的经典纽约市容造成了破坏,”历史街区保护委员会(Historic Districts Council)的执行董事西蒙·班考夫(Simon Bankoff)说,他同时指出,2015年将是纽约市通过《地标建筑保护法》的50周年。“环顾左右,那些总被我们认为是一成不变的东西,却都在纷纷关门闭户。”
尽管当下是一个全球性的经济环境,但仅有约20%的美国人会说第二门语言。Sixty Vocab的目标就是以其在线外语游戏改变这一现状。基于2000个单词相当于一门外语的六成精髓的假设,Sixty Vocab试图使学习必要词汇的过程变得有趣。这些在线游戏能教你在对话中最为常用的词汇,并辅以限制时间的规则——你在越短的时间内猜出单词,你就能越快地进入到下一个阶段。Sixty Vocab填补了你高中课程和昂贵外语学习项目之间的空白,为那些想要在早餐咖啡或通勤时间学习一门外语的人提供了一个独一无二的选择。
Here are the news events that the search engine Baidu says most captured Internet users' attention in 2015:
[s?'k?m]

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

1.《雨人》
File this under "great, yet stupid gift ideas." The BOx bottle opener claims to be the "world's first smart bottle opener" but it's not groundbreaking. This bottle opener sends a message to your friends via Messenger every time you open a bottle — crazy, right?

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

This is a thorny issue that’s unique to messaging apps. We expect ads to live alongside content we consume. We don’t expect them to crop up in our one-on-one communications. “The last thing you want in a personal conversation is a banner ad or pop-up that interrupts that,” Wray says. “It might work with more impersonal networks, but specifically within messaging, people hate traditional ads.”
Moving away from fossil fuels to renewable energy is surely the most important engineering and scientific challenge of our age.
n. 谷物,小麦,玉米

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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A party of 108 pandas – performers dressed in costumes – descended on London streets today to promote the plight of the cuddly black and white endangered species.
10. 《结果》(Results),导演:安德鲁·布西内斯克(Andrew Bujalski)。

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