Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
“That’s the first time we’ve seen that,” said Thomas Karl, director of the US National Oceanic and Atmospheric Administration’s national centres for environmental information.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
About 60 per cent have not yet worked and a further 30 per cent have less than two years’ experience.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
A tender love story between a teenager and an academic, set in Italy.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Just 21 millimeters long, 16 millimeters high, and 4 millimeters thick, the amulet, of which part is missing, has a “raised decoration” on it with a loop at one end that allowed it to be worn on a cord around the neck.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
A record 27,817 civil service jobs are being offered this year by central government departments and subsidiaries.
10. 《结果》(Results)，导演：安德鲁·布西内斯克(Andrew Bujalski)。
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Before long, Russell fell in love with inmate named Phillip Morris. After Morris was released, Russell again escaped prison by calling the clerk's office, impersonating a judge and drastically reducing his own bail. He was caught and escaped two more times to be with Morris, at one point faking his own death. He is now serving a life sentence but admits to finding his film portrayal pretty exciting.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Further, 32 out of the 50 new selected female billionaires started their businesses from scratch.
10. “移动珠宝”(Run the Jewels)，《移动珠宝2》，Mass Appeal。说到迫切和讥讽，杀手麦克(Killer Mike)和EL-P都是地下说唱界不同圈子里的资深人士了，他们组成的“移动珠宝”在第二张专辑里找到了坚实的互相吸引。他们的说唱强大有力，关注点狂热喧闹，专辑抨击没有让任何人摆脱困境的权力结构。
ACE2 as a potential therapeutic target for pandemic COVID-19
With a bit of help from Charles Dickens, let’s take a look back at the year in which almost nothing worked:
For: A huge box office hit that could benefit from a slowly-changing Oscar voting demographic.
Diagnostic technologies for COVID-19: a review
4. Manufacturing won't save the economy.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
8. Get Inspired
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Interestingly, BRICS bloc has reduced their exposure to these securities at a time when America's economic activity is expanding at a moderate rate.
If successful, Hurun estimates that Mr Wang’s net worth could soar past $50bn, making him one of the world’s 10 richest men.
Influenza neuraminidase: A druggable target for natural products
3. Tablets meet viruses.
Hope you enjoy the happiness of New Year and all the trimmings.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Judge for yourself.
3) I am often irritated 0 1 2 3 4
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
23岁的古纳尔?优素福(Gunal Youssouf)是Teach First人，她加入了普华永道(PwC)英国分公司的管理咨询毕业生项目。优素福表示，在Teach First的两年让她有机会在不用花钱攻读传统资格证书的情况下尝试教学工作。
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Lady Gaga以5.9千万位列第四，其后是5.45千万的碧昂斯。前者在统计期间演出了66场，也靠与范思哲和MAC的合约获得收入，同时还有她自己的黑色香水。后者与其老公Jay Z的On The Run巡回演唱会通过19天（北美日期），赚得了超过10千万，创造了能与滚石相比较的第一对音乐界夫妻档夜平均的神话。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Roth, 60, is a professor at Harvard University in Boston. Shapley, 89, is a professor emeritus at University of California Los Angeles.
However, you know when your cycles are over when the washer and dryer stop making noise. And you know when the weather is ugly by simply looking outside, or checking your weather app. Therefore, the product is basically just another way hackers can get into your home.
"A total of 297 projects will be carried out in Tongzhou, such as building new subway lines and expressways, and improving ecologies," Lu Yan, director of the Beijing Municipal Commission of Development and Reform, said at a news conference on Wednesday.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Master of None
Wishing you peace, joy and happiness through the coming year.在新年来临之际，祝福你平安、快乐、幸福！
会计和咨询机构德勤(Deloitte)英国分公司的企业责任主管克莱尔?伯顿(Claire Burton)表示，Teach First出来的人很受招聘人员的欢迎，因为他们擅长团队合作，有很强的领导能力。
Lawyers are inherently cautious but most have realised that technology is crucial to crunching through the vast amount of information they handle. Without it, certain document heavy processes, such as disclosure and compliance, would be nearly impossible.
Meanwhile, in recent months mainland investors have been rapidly owning equity trading accounts and putting money into the stock market. The Shanghai Composite has become the region's best performing index, rising nearly 45 per cent year to date.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
FKA twigs “Two Weeks” (Young Turks)
9. Occupational therapist
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
But we at The BostonConsulting Group believe that the current dip in China’s growth will not endureand that, under Xi’s leadership, China’s economy is destined to continuegrowing at a rapid clip. In fact, we are confident last week’s reforms willcontribute mightily to China’s growth between now and 2020. We stand by our base case forecast that China will deliver$4 trillion in growth over the next decade and combine with India to deliver a$10 trillion prize — an economic powerhouse driven by booming middle classconsumption and growing overall optimism. No one can perfectly forecastthe future … and in our book we describe scenarios where growthslows. But we remain optimistic and positive about China’s future.
此次涵盖95个项目（去年为90个）的排行榜中，来自7个国家的9所院校为首次进入榜单。排名第41位的法兰克福金融管理学院(Frankfurt School of Finance & Management)是今年排名最高的新入榜者。这家德国学院拥有性别比例最平衡的项目之一，女性占学员总数的49%。
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
当你听说今年3月份，一个17岁的学生把自己设计的一款软件以3,000万美元卖给雅虎公司(Yahoo! Inc., YHOO)的时候。对于这孩子的形貌，你脑海里或许已勾画出一个搞笑的形象了吧：不用说，肯定是个极客。一个除了一行一行写代码之外对什么也不感兴趣的学霸。一个不敢正眼瞧人还老小声儿嘀咕着什么的神经质。
这两部纪录片都使用标准工具——资料影像、人物采访，悉心选择的音乐资料——在目前的紧张局势中书写历史。在“黑人的命也是命”(Black Lives Matter)的时代，关于黑豹党和爵士歌手兼行动分子妮娜·西蒙妮的影片确实意义重大。尼尔逊和贾巴斯精彩地讲述了他们的故事。
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
This is the sixth edition of the QS World University Rankings by Subject, featuring a record-breaking 42 disciplines, making it the largest-ever ranking of the kind. The expert opinion of the world's top 76,798 academics and 44,426 employers informed the results, alongside the analysis of 28.5 million research papers and over 113 million citations sourced from the Scopus/Elsevier bibliometric database, said QS.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Company: Binary Group
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
“One employee’s parents contacted the company to let us know their son was resigning.
For example, taxi drivers who take a detour or refuse passengers can also be fined a maximum of 2,000 yuan.
You`d love to know the balance of forces that shape and move your ponytail, right? That`s why Joseph Keller, Raymond Goldstein, Patrick Warren and Robin Ball received this igNOMINIOUS prize!
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The report shows that compared with that in 2015, the percentage of graduates to start up business are significantly decreased from 6.3% to 3.1% in 2016.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
These artificial ears will be a huge benefit to those who suffer injuries or who have microtia, a condition that keeps the ears from ever developing.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
STEP 1: GET THE LOOK
Yet for all Russia's pretence about a rebalancing of priorities towards Asia, since the fallout over Ukraine, it still measures itself against the West, and America in particular.
In fact, one ancient saying was, "ifyou have Kucha, only one percent of the states in the Western Frontiers remain unsubmissive."
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Five development concept of innovation, harmonization, green, openness and sharing
小说作者安东尼·赫洛维兹（Anthony Horowitz）透露，新书《Trigger Mortis》为现代读者作了改动，包含反对吸烟的信息，而且首次有一位“直言不讳”的同性恋朋友出场。
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
We think of the passage of NBA time in seasons, for obvious reasons. There's connection, a continuum. It's how we remember things that happen, in the course of a season of play. But there's some benefit to looking back at a calendar year, January 1 to December 31, and what we've learned in that process. After all, many say the "unofficial start" to the NBA season is Christmas, with the new year starting soon after. So here are the lessons we learned about the NBA in the year 2017.
10.Be Dedicated and balanced
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
If you are spending time looking for other jobs while you are on the clock, it's obvious you want to leave your job. So keep looking for new jobs and as soon as you find a good one, take it and run.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Venice has long been hailed as one of the most romantic cities in the world, a must-visit lagoon city on many people's travel lists.
1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4：狂暴之路》(Mad Max: Fury Road)，并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片，二者都应该到你能找到的最大的屏幕上去看。
A modular microarray imaging system for highly specific COVID-19 antibody testing
Game of Thrones
"The Constitution really doesn't apply here. The Constitution limits how much government can suppress speech, not a private university," she said.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Anxiety about addiction to screen time gave rise to a dubious new line of businesses: boot camps, often run by ex-military personnel, promising to help wayward youth kick the habit. But investigative reports p ublished in recent days by Beijing News and the Mirror reveal abusive conditions, leading to the death of at least one student, at the Zhengzhou Boqiang New Idea Life Training School, which billed itself a s an Internet-addiction recovery camp in eastern Henan province.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
位于华盛顿特区的乔治敦大学(Georgetown University)麦克多诺商学院(McDonough business school)重新回到了定制课程排行榜的第15位，去年，该校因客户调查反馈率低而未上榜。只有3所学校是首次登上定制课程排行榜，包括排名第60位的伦敦卡斯商学院(Cass Business School)。
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Jackdaw Research的简?道森(Jan Dawson)表示，最近几个月“他表现得更加意气风发和充满自信”。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Both the film and the television series are adapted from the Taiwan action role-playing game of the same name which was developed by Softstar Entertainment. The game is considered by many as simply one of the best Chinese RPG's ever created.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Included will be messages about smoking causing cancer and women who give the charmer a run for his money as 'little twists' have been added to make the story suitable for the modern reader.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Many investors, it turns out, are siding with Mr Cook. After a tumultuous 2013, the share price has increased by around 50 per cent since that shareholder meeting, at one point taking its market capitalisation above $700bn.
adj. 暴露的，无掩蔽的，暴露于风雨中的 v. 暴露，
GAINS AND LOSSES IN A CHANGING WORLD
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
The GM turnaround will drag on. Forget a 2010 IPO.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Institutions may also fail.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
各大资产管理公司的专家们表示，评估亚洲ETF潜力的难题在于日本市场在地区所占比重过大，以及日本央行(Bank of Japan)扮演的角色过大。日本央行每年购买6万亿日元（合540亿美元）的ETF，这扭曲了市场。
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Forever pop's Number One rebel, Charli XCX returned with an excellent surprise mixtape.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Mrs. May’s government proposed a rule that would publicly shame employers who hired foreign workers. And her first major speech was full of barbs directed against multiculturalism, including a jab against people who claimed to be “citizens of the world,” whom she called “citizens of nowhere.”
When you post your résumé to a job board, such as Monster or Indeed, there's a chance your current employer could see it. In fact, Foss says many HR staffers and managers regularly search for their company names within job board submissions specifically to see if their employees are looking for jobs。
Length-scale dependence of protein hydration-shell density
“纽约人正逐渐意识到，这一漫长的繁荣期已对我们眼中的经典纽约市容造成了破坏，”历史街区保护委员会(Historic Districts Council)的执行董事西蒙·班考夫(Simon Bankoff)说，他同时指出，2015年将是纽约市通过《地标建筑保护法》的50周年。“环顾左右，那些总被我们认为是一成不变的东西，却都在纷纷关门闭户。”
尽管当下是一个全球性的经济环境，但仅有约20%的美国人会说第二门语言。Sixty Vocab的目标就是以其在线外语游戏改变这一现状。基于2000个单词相当于一门外语的六成精髓的假设，Sixty Vocab试图使学习必要词汇的过程变得有趣。这些在线游戏能教你在对话中最为常用的词汇，并辅以限制时间的规则——你在越短的时间内猜出单词，你就能越快地进入到下一个阶段。Sixty Vocab填补了你高中课程和昂贵外语学习项目之间的空白，为那些想要在早餐咖啡或通勤时间学习一门外语的人提供了一个独一无二的选择。
Here are the news events that the search engine Baidu says most captured Internet users' attention in 2015:
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
File this under "great, yet stupid gift ideas." The BOx bottle opener claims to be the "world's first smart bottle opener" but it's not groundbreaking. This bottle opener sends a message to your friends via Messenger every time you open a bottle — crazy, right?
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
This is a thorny issue that’s unique to messaging apps. We expect ads to live alongside content we consume. We don’t expect them to crop up in our one-on-one communications. “The last thing you want in a personal conversation is a banner ad or pop-up that interrupts that,” Wray says. “It might work with more impersonal networks, but specifically within messaging, people hate traditional ads.”
Moving away from fossil fuels to renewable energy is surely the most important engineering and scientific challenge of our age.
About this collection
A party of 108 pandas – performers dressed in costumes – descended on London streets today to promote the plight of the cuddly black and white endangered species.
10. 《结果》(Results)，导演：安德鲁·布西内斯克(Andrew Bujalski)。